In this episode, Margaret and I take on the en vogue topic of GLP-1s. They have been utilized for T2DM for several years and just recently took center stage in the zeitgeist for weight loss (medically indicated or otherwise). Today, we will break down possible risks to mental health in patients using these medications and, on the flipside, potential areas where we could possibly use GLP-1s primarily to treat mental illness.
Paper used:
Sa B, Maristany A, Subramaniam A, et al. Psychiatric effects of GLP-1 receptor agonists: A systematic review of emerging evidence. Diabetes Obes Metab. 2026;28(1):50-59. doi:10.1111/dom.70198
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Produced by Dr Glaucomflecken & Human Content
Get in Touch: howtobepatientpod.com
Chapters:
00:00 GLP-1 Cold Open
00:15 Podcast Intro and Topic
01:20 Gratitude Roundtable
02:01 Cats Kibble and Allergies
03:30 Loans Piercings and Health
09:44 Break and Sponsor Spot
10:53 GLP-1 Basics and Prevalence
16:49 Psych Effects Evidence
26:48 Masked Hunger Signals
27:17 Anxiety Study Breakdown
31:00 Suicide Risk Evidence
33:21 Psychosis Safety Update
34:47 GLP-1s And Substance Use
35:30 Reward Drive Vs Action
41:36 Binge Eating Benefits
49:54 Anhedonia And Final Takeaways
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