In this episode we're doing another journal club, this time reviewing the first randomized clinical trial comparing image-guided TMS to the traditional method using scalp targeting for depression. We walk through how TMS works, why targeting matters, what the study found at one month, and where the limitations are before this becomes standard of care.
Find the paper here: https://pubmed.ncbi.nlm.nih.gov/42340706/
Watch on YouTube: @itspresro
Listen Anywhere You Podcast: Apple, Spotify, PodChaser, etc.
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Produced by Dr Glaucomflecken & Human Content
Get in Touch: howtobepatientpod.com
Chapters:
00:00 Cost and Ethics Debate
00:26 Podcast Banter Setup
01:10 Why TMS Today
03:37 TMS Basics Physics
04:42 Targets and Limits
06:39 Logistics Risks Side Effects
09:56 Why Targeting Is Crude
14:00 The fMRI Guided Trial
20:49 Decoding Voxel Time Series
22:19 Narrowing the TMS Target
23:27 Break and Sponsor Spot
24:38 Results MADRS Improvements
25:42 Target Variability and Magnet Physics
29:47 Clinical Meaning and Placebo Limits
32:55 Access Ethics and Funding Tradeoffs
39:38 Wrap Up and Science vs Hype
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